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  2. Q: Can you donate blood when you have Protein S Deficiency? A: Yes, but there are restrictions. If you have had any thrombosis then you must not donate. If you are taking anticoagulants then you must not donate. *** Protein S Deficiency : Thrombosis You may give blood provided you have never had an episode of clotting and do not require anticoagulant medication to prevent clotting. Source: https://my.blood.co.uk/knowledgebase/Index/P *** Note: This is the general advice for Thrombosis. Thrombosis can be caused by other health conditions besides Protein S Deficiency. However if you have Protein S Deficiency then follow the advice shown above. Deep Vein Thrombosis : Thrombosis Pulmonary Embolism : Thrombosis You must not donate if you have been told you have atherosclerosis, if you have been told you have axillary vein thrombosis, you have had two or more episodes of thrombosis (blood clot) or you will be taking anticoagulant treatment (medication/injections to thin you blood) for life. If the cause of your thrombosis was one of the following, you may donate 7 days after completing any anti coagulant therapy to thin the blood as long as you have had a single episode only of thrombosis (blood clot): Contraceptive pill Long haul flight Plaster cast Immobility Smoking Following surgery Pregnancy Source: https://my.blood.co.uk/knowledgebase/Index/D Source: https://my.blood.co.uk/knowledgebase/Index/P
  3. Protein C and protein S deficiencies may be related to survival among hemodialysis patients Mayuri Ichinose, Naru Sasagawa, Tetsuo Chiba, Katsuhide Toyama, Yuzo Kayamori and Dongchon Kang BMC Nephrology 2019 20:191 Background: Thrombophilia due to protein C (PC) and protein S (PS) deficiencies is highly prevalent among patients with stage 5 chronic kidney disease and is reported to arise due to extracorporeal circulation during hemodialysis (HD). This study aimed to evaluate the relationship between HD treatment and thrombophilia. https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-019-1344-8 This study suggests that some patients undergoing dialysis treatment for kidney disease are more susceptible to thrombosis. The researchers confirmed that the patients in the study did not have a hereditary cause of protein deficiency. However those that had acquired a protein deficiency also had reduced survival rates.
  4. Thanks James, you rested my mind. I'm always anxious about my health since I got to know that I have PSD tough my doctor don't seem concerned as he said it's borderline.
  5. When you are travelling on anticoagulants you are in a better position than other passengers. They may have an undiagnosed risk and they have no protection at all. Whereas you have medication to protect you, and you are aware of possible symptoms, and can take additional precautions seriously. https://www.proteinsdeficiency.com/lifestyle/air-travel.php I have flown from UK to Australia on my standard dosage of Warfarin... there is no need for anything more than usual however if you a doing any long distance travel it helps if you can visit your doctor beforehand to confirm you are fit to fly. Let the doctor do their job and advise you what is best for you based on your medical history.
  6. Hi to all, I'm new here and I would like to excuse my self for my English writing as I'm from Malta. I was diagnosed with protein s deficiency after my 3rd miscarriage in 2014. They started clopidogrel 1 year ago as while I was on work my right arm got weak. They did all the test ecg,brain scan ,blood and neck ultrasound, all came back fine. My levels are Protein s activity 51 Protein is free functional 50 I'm having panic attacks and can't enjoy life as I'm always afraid that the stroke will hit me in any time, also I'm afraid of travelling which I have to do with my 13 year old daughter as she takes alot of ballet courses in UK.I asked the doctor to do the test again but he said there is no need the levels are what they are:(.
  7. Full article available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752078/
  8. As an update to my previous post we took out a joint policy with LV (Liverpool Victoria). I declared my health history and PSD and was given cover with an extra premium to pay. A ten year policy for £80k costs us £25.51 per month. This doesn’t pay off the mortgage but it ensures that after debts and funeral costs the amount left for the other person to pay would be affordable.
  9. Early Identification of Protein S K196E Mutation in a Patient With Cerebral Venous Thrombosis: A Case Report https://www.sciencedirect.com/science/article/pii/S1052305718305627 Background Mutation of protein S K196E (PS K196E) is a genetic risk factor for venous thromboembolism; however, there are few reports on cerebral venous thrombosis (CVT) with this mutation. We report a case of CVT that was diagnosed as having PS K196E mutation at the initial thrombotic event. Methods A 54-year-old man suddenly developed generalized seizures after headache and nausea. Brain magnetic resonance imaging showed cerebral edema, and angiography revealed CVT. Blood examination revealed that protein S activity was low (44%) despite normal free protein S antigen levels (81%). Sequence analysis revealed a heterozygous PS K196E mutation. We treated him with warfarin with the international normalized ratio maintained at 2.0-3.0. After 1 month, he was discharged without any neurological sequelae. Results Early identification of the causes of thrombophilia is important for the long-term management of CVT. However, detection of PS K196E mutation is difficult because its only feature is a moderate decrease in the activity of protein S, which is influenced by environmental factors. Conclusions The possibility of PS K196E mutation should be considered if other causes of CVT are ruled out and if protein S activity is decreased.
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