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  2. Yes you can fly wearing compression stockings. When you are seated you can also do heel-toe exercises to improve circulation. Start with feet on the floor, flat and level, keep the heal on the ground and lift your toes. These also help... https://www.livestrong.com/article/462835-exercises-for-swollen-feet/ Be aware of symptoms after flying for up to six weeks, and act on any concerns by getting checked as soon as possible.
  3. Hi James, I am the first in my family to be diagnosed with PSD My sister was tested and has the possibility but no symptoms yet. I am now switched from coumadin to Pradaxa for life. I have had 4 previous clots, 3 after taking coumadin so that is why I now have Pradaxa. I need to learn more about this condition and drug so that is why I am on this site. Anything you learn and can pass on will be greatly appreciated. Do you know if the University fof N C has any new info? Thanks, Lois Lynda
  4. Hello Mary, Thanks for your reply. Sounds like you are doing fine. I have had 4 blood clots since 2012 and started at the onset with coumadin for life but after my last one in May 2019 my doctor switched me to Pradaxa. It was discovered that I have Protein S Deficiency. I wear compression stockings and lead a most normal life (with a few bumps in the road). I just want to learn more about this condition because I want to live a long and happy life. Thanks and best wishes, Lois Lynda
  5. Thanks for your tips. Yes I am fortunate and my goal is to live to be 100 with a happy life! Lois Lynda
  6. Hi Lois I had my first clot at age 30. Lots of people with PSD have clots in early adulthood so you've done well to get to your 70s before having one. That said, its a shock at any age and having to make accommodations in life is harder the older we get. There's a thread here on the forum where people have posted where they do and which doctors they see. It's a bit old but specialists tends to stick around so have a look there and see if ether is anyone close to you. Wearing compression is good and keeping moving is also good. In the beginning I kept my leg up as much as I could, mainly because it hurt if I didn't! . Any time I sat down I rested by foot on something to my foot was in line with my knee. I lifted the end of my bed so that my foot was higher than my hip when asleep and that way I started the day with a pain free and slim-ish leg. This will help your varicose veins as well as general swelling in your leg. It took years to reduce the swelling in my leg and now I still wear compression because I have what's called Post Thrombotic Syndrome- basically I still have pain if I stand for 5-10 minutes without compression. I can manage a shower then I really have to put my stocking on to go about the rest of my day. As there's nothing we can do about the PSD, the anticoagulants are our shield and everything else is about reducing pain and swelling so that we don't feel limited. Elevation, compression and movement at the things to focus on and bearing weight on your leg to make the 'foot pump' vein in the sole of the foot do the work to push blood back up the leg. I hope some of this helps. Although it can feel lonely and bewildering, you are not alone on this journey. If you are struggling to put stockings on this is a good way to do it. (I think her stocking is loose so easier to get on though!)
  7. Thanks for your reply. I also use my phone to remind me in the evening to take Pradaxa. I take it every A M when I wake up. My doctor recommended this med because you do not have to monitor Vit K intake. I am 77 and had my first clot (of 4) in 2011. My last one was this past May when my doctor switched me to Pradaxa. I live in the San Francisco Bay area and wanted to see a specialist for PSD but none seem to be located here. I read that N C had some . Do you know of any? I am worried about clots developing and traveling to the lungs where I had them before. I have bad varicose veins in my left leg, wear medical support stockings, and try to stay physically active to keep the blood moving. Would you please share any knowledge you may have or comments about treatments/techniques that have worked for you? Thanks so much. LLG
  8. Hello and welcome! Have you had a clot? Is that why you are taking Pradaxa? I take Pradaxa to reduce the risk of having another clot. I have Protein S Deficiency and had a long ankle to groin clot in 2003. There isn't any treatment for PSD and usually you will only be prescribed anticoagulants like coumadin, warfarin, Pradaxa, and Rivaroxaban when you have had a clot and it is likely that you may have another. The only trouble I have with Pradaxa is remembering to take it twice a day! I have an app on my phone to remind me and that helps. This forum is anonymous but if you don't mind being known by your name and friends seeing your posts about PSD you can join our facebook group https://www.facebook.com/groups/2506274438/
  9. Hello All, I am currently on a new medication to treat PSD calle Pradaxa. I would like to know if anyone else is on this medication and what their experiences have been with this new treatment. Also, I'd like to know if you have any advice. I would love to connect with others with PSD to share our experiences.
  10. Tumour-Secreted Protein S (ProS1) Activates a Tyro3-Erk Signalling Axis and Protects Cancer Cells from Apoptosis by Nour Al Kafri and Sassan Hafizi https://www.mdpi.com/2072-6694/11/12/1843/htm Abstract The TAM subfamily (Tyro3, Axl, MerTK) of receptor tyrosine kinases are implicated in several cancers, where they have been shown to support primary tumorigenesis as well as secondary resistance to cancer therapies. Relatively little is known about the oncogenic role of Tyro3, including its ligand selectivity and signalling in cancer cells. Tyro3 showed widespread protein and mRNA expression in a variety of human cancer cell lines. In SCC-25 head and neck cancer cells expressing both Tyro3 and Axl, Western blotting showed that both natural TAM ligands ProS1 and Gas6 rapidly stimulated Tyro3 and Erk kinase phosphorylation, with ProS1 eliciting a greater effect. In contrast, Gas6 was the sole stimulator of Axl and Akt kinase phosphorylation. In MGH-U3 bladder cancer cells, which express Tyro3 alone, ProS1 was again the stronger stimulator of Tyro3 and Erk stimulation but additionally stimulated Akt phosphorylation. Conditioned medium from ProS1-secreting 786-0 kidney cancer cells replicated the kinase activation effects of recombinant ProS1 in SCC-25 cells, with specificity confirmed by ProS1 ligand traps and warfarin. In addition, ProS1 protected cancer cells from acute apoptosis induced by staurosporine, as well as additionally, long-term serum starvation-induced apoptosis in MGH-U3 cells (Tyro3 only), which reflects its additional coupling to Akt signalling in these cells. In conclusion, we have shown that ProS1 is a tumour-derived functional ligand for Tyro3 that supports cancer cell survival. Furthermore, the ProS1-Tyro3 interaction is primarily coupled to Erk signalling although it displays signalling diversity dependent upon its representative expression as a TAM receptor in tumour cells. Extracts from the full text Our data also reveal a greater significance for the role of ProS1 as a TAM ligand than had previously been known in extra-hepatic tissues and beyond its well-established role in regulation of blood coagulation Therefore, our data demonstrate that cancer cells can be a major source of functional ProS1, expressed and modified post-translationally in a vitamin K-dependent process exactly as that which exists for several vitamin K-dependent proteins in the liver
  11. Hi I had a dvt last April 2019. It's cleared now 6 month finished . Treatment heparin raise 7 days. 3 months eliquis 5 mg twise a day and Ecosprin AV 75 mg ONE a day. Pressure tab. Now I am taking only one a day in EcosprinAv 75 mg. Can I fly & wearing compression stockings. Please let me know. Thax
  12. Hello, this is a super old post, are you still picking up from here? If yes id live to speak to you to find out how things are now and how youve managed both issues together
  13. Q: Can you donate blood when you have Protein S Deficiency? A: Yes, but there are restrictions. If you have had any thrombosis then you must not donate. If you are taking anticoagulants then you must not donate. *** Protein S Deficiency : Thrombosis You may give blood provided you have never had an episode of clotting and do not require anticoagulant medication to prevent clotting. Source: https://my.blood.co.uk/knowledgebase/Index/P *** Note: This is the general advice for Thrombosis. Thrombosis can be caused by other health conditions besides Protein S Deficiency. However if you have Protein S Deficiency then follow the advice shown above. Deep Vein Thrombosis : Thrombosis Pulmonary Embolism : Thrombosis You must not donate if you have been told you have atherosclerosis, if you have been told you have axillary vein thrombosis, you have had two or more episodes of thrombosis (blood clot) or you will be taking anticoagulant treatment (medication/injections to thin you blood) for life. If the cause of your thrombosis was one of the following, you may donate 7 days after completing any anti coagulant therapy to thin the blood as long as you have had a single episode only of thrombosis (blood clot): Contraceptive pill Long haul flight Plaster cast Immobility Smoking Following surgery Pregnancy Source: https://my.blood.co.uk/knowledgebase/Index/D Source: https://my.blood.co.uk/knowledgebase/Index/P
  14. Protein C and protein S deficiencies may be related to survival among hemodialysis patients Mayuri Ichinose, Naru Sasagawa, Tetsuo Chiba, Katsuhide Toyama, Yuzo Kayamori and Dongchon Kang BMC Nephrology 2019 20:191 Background: Thrombophilia due to protein C (PC) and protein S (PS) deficiencies is highly prevalent among patients with stage 5 chronic kidney disease and is reported to arise due to extracorporeal circulation during hemodialysis (HD). This study aimed to evaluate the relationship between HD treatment and thrombophilia. https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-019-1344-8 This study suggests that some patients undergoing dialysis treatment for kidney disease are more susceptible to thrombosis. The researchers confirmed that the patients in the study did not have a hereditary cause of protein deficiency. However those that had acquired a protein deficiency also had reduced survival rates.
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