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  3. Related topic on MERTK... https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0225051 The role of endothelial MERTK during the inflammatory response in lungs
  4. Role of Vitamin K-Dependent Factors Protein S and GAS6 and TAM Receptors in SARS-CoV-2 Infection and COVID-19-Associated Immunothrombosis by Anna Tutusaus 1, Montserrat Marí 1, José T. Ortiz-Pérez 2,3, Gerry A. F. Nicolaes 4, Albert Morales 1,5,* and Pablo García de Frutos 1,3,* Cells 2020, 9(10), 2186; https://doi.org/10.3390/cells9102186 (registering DOI) https://www.mdpi.com/2073-4409/9/10/2186 The vitamin K-dependent factors protein S (PROS1) and growth-arrest-specific gene 6 (GAS6) and their tyrosine kinase receptors TYRO3, AXL, and MERTK, the TAM subfamily of receptor
  5. I have Protein S deficiency. I have been on warfarin since I was diagnosed. I'm glad more work is being done on this.
  6. UK Researchers Identify COVID-19 Blood Clotting Cause By Elizabeth Chapin https://uknow.uky.edu/research/uk-researchers-identify-covid-19-blood-clotting-cause LEXINGTON, Ky. (Sept. 17, 2020) — A new University of Kentucky College of Medicine study may provide answers for why so many COVID-19 patients experience thrombosis, or the formation of blood clots that obstruct blood flow through the circulatory system. The research led by Jeremy Wood, Zach Porterfield and Jamie Sturgill in the Department of Internal Medicine; Beth Garvy in Microbiology, Immunology & Molecular Ge
  7. I’ve heard that Eliquis and Pradaxa are not really suitable for treating Protein S or C deficiency. Is this true? I’m on Warfarin and want to avoid the regular INR CHECKING AND FLUCTUATION ISSUES.
  8. Anticoagulant protein S – new insights on interactions and functions Magdalena Gierula, Josefin Ahnström First published: 23 July 2020 https://doi.org/10.1111/jth.15025 Protein S is a critical regulator of coagulation that functions as a cofactor for the activated protein C (APC) and tissue factor pathway inhibitor (TFPI) pathways. It also has direct anticoagulant functions, inhibiting the intrinsic tenase and prothrombinase complexes. Through these functions, protein S regulates coagulation during both its initiation and its propagation phases. The importance of protein S in haemo
  9. A medical research paper (by Rezende, Simmonds, Lane) suggested Protein S Deficiency may be related to other health conditions besides thrombosis. This is because Protein S interacts with the C4b-binding protein (C4BP). In their conclusion they asked the question: what are the consequences of reduced levels of Protein S on C4BP, and could it be linked to inflammation and autoimmune diseases? Together, we may be able to help answer that question. David Hansson is currently researching this issue and has created an online survey asking about any additional diseases and symptoms affe
  10. Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S–C4b binding protein complex Suely Meireles Rezende, Rachel Elizabeth Simmonds, David Anthony Lane Blood (2004) 103 (4): 1192–1201. Abstract Protein S (PS) has an established role as an important cofactor to activated protein C (APC) in the degradation of coagulation cofactors Va and VIIIa. This anticoagulant role is evident from the consequences of its deficiency, when there is an increased risk of venous thromboembolism. In human plasma, PS circulates approximately 40% as free PS (FPS)
  11. Last year I started to get problems with loss of sensation in my feet. I thought it was best to get it checked out because of concerns about reduced circulation with my DVT history and post thrombotic syndrome. I had a CT scan and saw an MSK consultant (musculoskeletal), a physio, and then a neurologist. I was subsequently diagnosed with mild peripheral neuropathy. It isn't related to Protein S Deficiency. And there isn't much they can do about it. Just to be sure, the neurologist then requested a wide range of blood tests, and one of the results came back with an odd result. There a
  12. If you are wearing Sigvaris compression stockings please be aware of a product name change. The type known as "Cotton" is now known as "Essential Thermoregulating". This change affects UK prescription re-ordering. Unfortunately the NHS system does not include the article number (which has not changed) so when re-ordering "Cotton" it will appear to be unavailable. Instead your GP needs to search for "Ess Thermo". If they need any assistance they can call Sigvaris UK on +44 1264 326 666
  13. Press release from Bristol-Myers Squibb https://www.bms.com/assets/bms/ca/documents/productmonograph/CANADA-Coumadin-deletion_D-HCP-Communication_FINAL_EN_04.23.2020.pdf Date: April 23, 2020 RE: Discontinuation of Sale and Distribution of Coumadin® (warfarin sodium) Tablets, for oral use. Dear Healthcare Professional, Bristol-Myers Squibb Canada would like to inform you that the sale and distribution of all strengths of Coumadin® (warfarin sodium) tablets will be discontinued in the United States, Canada, Latin America, and Saudi Arabia, due to an unexpected manufac
  14. RIP my dearest Mumsy Zarin. You are always and shall always be remembered. I miss you. Luv, Ah Chew
  15. Yes you can fly wearing compression stockings. When you are seated you can also do heel-toe exercises to improve circulation. Start with feet on the floor, flat and level, keep the heal on the ground and lift your toes. These also help... https://www.livestrong.com/article/462835-exercises-for-swollen-feet/ Be aware of symptoms after flying for up to six weeks, and act on any concerns by getting checked as soon as possible.
  16. Hi James, I am the first in my family to be diagnosed with PSD My sister was tested and has the possibility but no symptoms yet. I am now switched from coumadin to Pradaxa for life. I have had 4 previous clots, 3 after taking coumadin so that is why I now have Pradaxa. I need to learn more about this condition and drug so that is why I am on this site. Anything you learn and can pass on will be greatly appreciated. Do you know if the University fof N C has any new info? Thanks, Lois Lynda
  17. Hello Mary, Thanks for your reply. Sounds like you are doing fine. I have had 4 blood clots since 2012 and started at the onset with coumadin for life but after my last one in May 2019 my doctor switched me to Pradaxa. It was discovered that I have Protein S Deficiency. I wear compression stockings and lead a most normal life (with a few bumps in the road). I just want to learn more about this condition because I want to live a long and happy life. Thanks and best wishes, Lois Lynda
  18. Thanks for your tips. Yes I am fortunate and my goal is to live to be 100 with a happy life! Lois Lynda
  19. Hi Lois I had my first clot at age 30. Lots of people with PSD have clots in early adulthood so you've done well to get to your 70s before having one. That said, its a shock at any age and having to make accommodations in life is harder the older we get. There's a thread here on the forum where people have posted where they do and which doctors they see. It's a bit old but specialists tends to stick around so have a look there and see if ether is anyone close to you. Wearing compression is good and keeping moving is also good. In the beginning I kept my leg up as much as I could,
  20. Thanks for your reply. I also use my phone to remind me in the evening to take Pradaxa. I take it every A M when I wake up. My doctor recommended this med because you do not have to monitor Vit K intake. I am 77 and had my first clot (of 4) in 2011. My last one was this past May when my doctor switched me to Pradaxa. I live in the San Francisco Bay area and wanted to see a specialist for PSD but none seem to be located here. I read that N C had some . Do you know of any? I am worried about clots developing and traveling to the lungs where I had them before. I have bad varicose veins
  21. Hello and welcome! Have you had a clot? Is that why you are taking Pradaxa? I take Pradaxa to reduce the risk of having another clot. I have Protein S Deficiency and had a long ankle to groin clot in 2003. There isn't any treatment for PSD and usually you will only be prescribed anticoagulants like coumadin, warfarin, Pradaxa, and Rivaroxaban when you have had a clot and it is likely that you may have another. The only trouble I have with Pradaxa is remembering to take it twice a day! I have an app on my phone to remind me and that helps. This forum is anonymous but if you don't mind
  22. Hello All, I am currently on a new medication to treat PSD calle Pradaxa. I would like to know if anyone else is on this medication and what their experiences have been with this new treatment. Also, I'd like to know if you have any advice. I would love to connect with others with PSD to share our experiences.
  23. Tumour-Secreted Protein S (ProS1) Activates a Tyro3-Erk Signalling Axis and Protects Cancer Cells from Apoptosis by Nour Al Kafri and Sassan Hafizi https://www.mdpi.com/2072-6694/11/12/1843/htm Abstract The TAM subfamily (Tyro3, Axl, MerTK) of receptor tyrosine kinases are implicated in several cancers, where they have been shown to support primary tumorigenesis as well as secondary resistance to cancer therapies. Relatively little is known about the oncogenic role of Tyro3, including its ligand selectivity and signalling in cancer cells. Tyro3 showed widespread protein and mR
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