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James

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  1. UK Researchers Identify COVID-19 Blood Clotting Cause By Elizabeth Chapin https://uknow.uky.edu/research/uk-researchers-identify-covid-19-blood-clotting-cause LEXINGTON, Ky. (Sept. 17, 2020) — A new University of Kentucky College of Medicine study may provide answers for why so many COVID-19 patients experience thrombosis, or the formation of blood clots that obstruct blood flow through the circulatory system. The research led by Jeremy Wood, Zach Porterfield and Jamie Sturgill in the Department of Internal Medicine; Beth Garvy in Microbiology, Immunology & Molecular Ge
  2. Anticoagulant protein S – new insights on interactions and functions Magdalena Gierula, Josefin Ahnström First published: 23 July 2020 https://doi.org/10.1111/jth.15025 Protein S is a critical regulator of coagulation that functions as a cofactor for the activated protein C (APC) and tissue factor pathway inhibitor (TFPI) pathways. It also has direct anticoagulant functions, inhibiting the intrinsic tenase and prothrombinase complexes. Through these functions, protein S regulates coagulation during both its initiation and its propagation phases. The importance of protein S in haemo
  3. A medical research paper (by Rezende, Simmonds, Lane) suggested Protein S Deficiency may be related to other health conditions besides thrombosis. This is because Protein S interacts with the C4b-binding protein (C4BP). In their conclusion they asked the question: what are the consequences of reduced levels of Protein S on C4BP, and could it be linked to inflammation and autoimmune diseases? Together, we may be able to help answer that question. David Hansson is currently researching this issue and has created an online survey asking about any additional diseases and symptoms affe
  4. Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S–C4b binding protein complex Suely Meireles Rezende, Rachel Elizabeth Simmonds, David Anthony Lane Blood (2004) 103 (4): 1192–1201. Abstract Protein S (PS) has an established role as an important cofactor to activated protein C (APC) in the degradation of coagulation cofactors Va and VIIIa. This anticoagulant role is evident from the consequences of its deficiency, when there is an increased risk of venous thromboembolism. In human plasma, PS circulates approximately 40% as free PS (FPS)
  5. Last year I started to get problems with loss of sensation in my feet. I thought it was best to get it checked out because of concerns about reduced circulation with my DVT history and post thrombotic syndrome. I had a CT scan and saw an MSK consultant (musculoskeletal), a physio, and then a neurologist. I was subsequently diagnosed with mild peripheral neuropathy. It isn't related to Protein S Deficiency. And there isn't much they can do about it. Just to be sure, the neurologist then requested a wide range of blood tests, and one of the results came back with an odd result. There a
  6. If you are wearing Sigvaris compression stockings please be aware of a product name change. The type known as "Cotton" is now known as "Essential Thermoregulating". This change affects UK prescription re-ordering. Unfortunately the NHS system does not include the article number (which has not changed) so when re-ordering "Cotton" it will appear to be unavailable. Instead your GP needs to search for "Ess Thermo". If they need any assistance they can call Sigvaris UK on +44 1264 326 666
  7. Press release from Bristol-Myers Squibb https://www.bms.com/assets/bms/ca/documents/productmonograph/CANADA-Coumadin-deletion_D-HCP-Communication_FINAL_EN_04.23.2020.pdf Date: April 23, 2020 RE: Discontinuation of Sale and Distribution of Coumadin® (warfarin sodium) Tablets, for oral use. Dear Healthcare Professional, Bristol-Myers Squibb Canada would like to inform you that the sale and distribution of all strengths of Coumadin® (warfarin sodium) tablets will be discontinued in the United States, Canada, Latin America, and Saudi Arabia, due to an unexpected manufac
  8. Yes you can fly wearing compression stockings. When you are seated you can also do heel-toe exercises to improve circulation. Start with feet on the floor, flat and level, keep the heal on the ground and lift your toes. These also help... https://www.livestrong.com/article/462835-exercises-for-swollen-feet/ Be aware of symptoms after flying for up to six weeks, and act on any concerns by getting checked as soon as possible.
  9. Tumour-Secreted Protein S (ProS1) Activates a Tyro3-Erk Signalling Axis and Protects Cancer Cells from Apoptosis by Nour Al Kafri and Sassan Hafizi https://www.mdpi.com/2072-6694/11/12/1843/htm Abstract The TAM subfamily (Tyro3, Axl, MerTK) of receptor tyrosine kinases are implicated in several cancers, where they have been shown to support primary tumorigenesis as well as secondary resistance to cancer therapies. Relatively little is known about the oncogenic role of Tyro3, including its ligand selectivity and signalling in cancer cells. Tyro3 showed widespread protein and mR
  10. Q: Can you donate blood when you have Protein S Deficiency? A: Yes, but there are restrictions. If you have had any thrombosis then you must not donate. If you are taking anticoagulants then you must not donate. *** Protein S Deficiency : Thrombosis You may give blood provided you have never had an episode of clotting and do not require anticoagulant medication to prevent clotting. Source: https://my.blood.co.uk/knowledgebase/Index/P *** Note: This is the general advice for Thrombosis. Thrombosis can be caused by other health conditions besides Protein S Defi
  11. Protein C and protein S deficiencies may be related to survival among hemodialysis patients Mayuri Ichinose, Naru Sasagawa, Tetsuo Chiba, Katsuhide Toyama, Yuzo Kayamori and Dongchon Kang BMC Nephrology 2019 20:191 Background: Thrombophilia due to protein C (PC) and protein S (PS) deficiencies is highly prevalent among patients with stage 5 chronic kidney disease and is reported to arise due to extracorporeal circulation during hemodialysis (HD). This study aimed to evaluate the relationship between HD treatment and thrombophilia. https://bmcnephrol.biomedcentral.com/articles/10.
  12. When you are travelling on anticoagulants you are in a better position than other passengers. They may have an undiagnosed risk and they have no protection at all. Whereas you have medication to protect you, and you are aware of possible symptoms, and can take additional precautions seriously. https://www.proteinsdeficiency.com/lifestyle/air-travel.php I have flown from UK to Australia on my standard dosage of Warfarin... there is no need for anything more than usual however if you a doing any long distance travel it helps if you can visit your doctor beforehand to confirm you are fit to
  13. Full article available at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752078/
  14. As an update to my previous post we took out a joint policy with LV (Liverpool Victoria). I declared my health history and PSD and was given cover with an extra premium to pay. A ten year policy for £80k costs us £25.51 per month. This doesn’t pay off the mortgage but it ensures that after debts and funeral costs the amount left for the other person to pay would be affordable.
  15. Early Identification of Protein S K196E Mutation in a Patient With Cerebral Venous Thrombosis: A Case Report https://www.sciencedirect.com/science/article/pii/S1052305718305627 Background Mutation of protein S K196E (PS K196E) is a genetic risk factor for venous thromboembolism; however, there are few reports on cerebral venous thrombosis (CVT) with this mutation. We report a case of CVT that was diagnosed as having PS K196E mutation at the initial thrombotic event. Methods A 54-year-old man suddenly developed generalized seizures after headache and nausea. Brain magne
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