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About James

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  • Birthday 09/10/1969

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  1. Fasting (water only)

    Warfarin can be taken with or without food. Fasting is known to increase the INR of patients taking warfarin. However warfarin dosage can be adjusted to take this into account, so the key point is whether the INR is stable. This varies from patient to patient anyway, however fasting adds a new element into the equation. If this became a problem one option to explore would be having a Vitamin K supplement to help stabilise the INR.
  2. I have seen forum posts where it was mentioned as a contraindication on the bottle. After searching I found these... https://www.tabletwise.com/medicine/nattokinase/contraindications http://nattokinasehearthealth.com/26/side-effects-and-dangers/
  3. Does your doctor know that you take nattokinase... I know there are some people who say it works and some who say it doesn’t (I prefer to keep an open mind) however I have read that warfarin and nattokinase shouldn’t be mixed. Maybe it is worth starting a new topic just about nattokinase, your experience with it, and gathering up some of the medical literature?
  4. Just to update with couple of comments, even though this topic is from a year or two ago: 1/ If you have hereditary Protein S Deficiency you do not need to be concerned about Vitamin K unless you are taking anticoagulants such as warfarin (brand name, Coumadin). If you are taking warfarin you will be encouraged to manage your natural Vitamin K dietary intake because it interacts with the drug and affects dosage requirements. In some cases, to help smooth out dosage requirements you may be asked to take a Vitamin K supplement but you should only do this if directed. 2/ If you have acquired Protein S Deficiency this may be caused by pregnancy and other health conditions. For example celiac disease, cystic fibrosis, and digestive issues can lead to a deficiency of Vitamin K, which in turn can reduce production of Protein S. Most of our Vitamin K comes from our diet and digestion so it is unusual for the average adult to have a Vitamin K deficiency. A new born baby is given a booster shortly after delivery to make up for the lower level they start out with, bearing in mind their dietary intake will come later when they start feeding. However having too much Vitamin K can be harmful (especially for kidney disorders), so you should avoid taking supplements unless directed. And you don’t need Vitamin K in your diet every day because any that is surplus to your body’s immediate requirements is stored in the liver for future use.
  5. Stroke

    If you look at the test result it should give you a range for a normal result. Usually this is 58-125, which would mean that 72 is normal, and therefore not a cause for concern. The other thing to bear in mind is this test was after your stroke, not before, and clotting can affect the outcome of results.
  6. Sandie, the photos you uploaded showed: Protein S Ag Free Result 20 Range 50-160 Your result is low. Total Protein S Antigen assesses the Protein S deficiency as either Type I or III (IIa). (source)
  7. Rest in Peace Bela, our thoughts are with you and your family.
  8. http://www.bendbulletin.com/obituaries/5790875-151/bela-lain-moynier Feb. 10, 1979 - Nov. 19, 2017 Bela Lain Moynier passed away suddenly at his home in Bend, Oregon on November 19, 2017. He is survived by his mother, Jo Ann Moynier Barnum; father, William (Bill) Moynier; step-father, Ed Barnum; grandmother, Verla Stidman; aunts, uncles and cousins. He is also survived by close friend and housemate, Ron Paradis. Bela was born in San Diego, California, on February 10, 1979. He attended grade and middle schools in Eugene, OR. He graduated from Bakersfield High School. He studied at Lane Community College and COCC. At age three Bela wowed his audience playing violin Suzuki style, his music talent inherited from father and father's parents. He loved the martial arts, was a ninja at heart and had natural abilities with art. He had a passion for baseball, also inherited from father and paternal grandfather, and was an avid Dodgers fan. He excelled in basketball and soccer. His mother primarily raised him in his early life, supporting him in every way. He would often have half dozen friends sleep over at his home, where he also interacted with many foreign students who lived there. At age eleven, he lived six months in Australia with his dad, who shared a teacher exchange. He sky dived and scuba dived with his mother. Belas family invite their friends to join them at the home of his mother and step-father at 65859 White Rock Loop on Saturday, December 2 from 1-5 p.m. to celebrate his life. Donations may be made in his name to the charity of one's choice with suggestion of helping the homeless and research for a cure for protein 'S' deficiency. Please visit the online registry for Bela at www.niswonger-reynolds.com
  9. You said her INR was always too low, so I assume she has been taking Coumadin or warfarin. The dosage of this medication depends on the response by the patient, some people take 2mg and someone else takes 20mg and gets the same response. What was her last INR result and the dosage she was on? How long was it in days/weeks between INR tests?
  10. Testing Children for PSD

    Q: If you have Protein S Deficiency and have children, when should you get them tested? A: There is no need to test them, unless there is another risk factor for thrombosis. The statistics show that about half of the people with a deficiency of Protein S stay clot free throughout their lifetime. The other half tend to experience their first clot in late teens or early twenties. Medication, in the form of anticoagulants, is only given to people with a history of thrombosis. So until you have your first clot, you don’t know which half you are going to belong to. And until you have your first clot you aren’t going to be taking the anticoagulants that would have prevented it. This seems a bit bizarre until you consider the cost of blood testing, medication side-effects (and risk of uncontrolled bleeding), and how health services tend to operate. Most of the time health services are responding to a change in health, then diagnosing and treating. It is very rare for a health service to extend to preventative actions unless it is cost effective or save lives (e.g. vaccinations). The cost of treating a few patients with thrombosis is cheaper than testing the whole population for the all the different risk factors. However things are slightly different if you already know someone related to you has already been diagnosed with Protein S Deficiency. But a blood test isn’t going to tell you whether you will or won’t go on to have thrombosis, and so you won’t be put on anticoagulants. So all a blood test will actually do is cause you to worry more about the future, and perhaps exclude you from health insurance or force your hand into declaring it as a pre-existing condition. So why bother? If you are a teenage girl considering birth control measures, then testing is advised before you take any pills. There is an increased risk of thrombosis with some contraceptives, so if there is any family history of PSD or thrombosis then get your PSD status checked first. If you are teenage girl and are planning to, or think you may be pregnant then also get yourself tested because it is relevant to the care of your baby and the doctors will want to know about it. Other than that, assume that it is good and healthy and sensible to take precautions in certain circumstances, such as if you have an extended stay in hospital (e.g. a broken leg) or taking a long journey (plane, train, whatever). Precautions means staying hydrated, avoiding alcohol, exercise normally, staying the right side of obesity, and maybe wear some compression stockings. Everyone can do this, you do not have to be diagnosed with PSD to reduce the risks of thrombosis. If you are under twenty and want to get yourself checked then by all means do so. However even if you are given a PSD diagnosis the doctor isn’t going to give you anticoagulants. And without them you may find out the hard way whether you are one of those people that gets to experience their first thrombosis event. But do so, knowing that the symptoms can be recognised and treatment is available. Not getting tested is probably the most practical way forward... it makes no difference to your actual risk of thrombosis... but at least you can keep your medical history to yourself and gain the benefit of insurance cover. A simple (D-Dimer) blood test can rule out a false alarm... so always get yourself checked if unsure. If the blood test comes back positive they will do an ultrasound to see what is going on, then give you a drip with some heparin (an anticoagulant) and you’ll probably be back home in a week or two. Life goes on, and then you start reading about it on the Internet. It affects some people worse than others but generally it is a health condition that can be managed, there is nothing to be worried about, and what will be, will be. Of course, with hindsight, I would like to have been diagnosed correctly after my first episode of thrombosis. Had that been done then I could have avoided the (more serious) Pulmonary Embolism (clot in the lungs) I experienced a year later. For accurate testing you need to wait 3 months, come off warfarin/Coumadin and have two blood tests (twice, as a safeguard against lab error). And of course, understanding risk is a personal thing. If you want to get tested please go ahead and do so. But be aware that the result is unlikely to change the risk of thrombosis but you may find yourself declaring the tests when applying for medical cover and travel insurance.
  11. I know that ECG results can detect a history of PE, but I am not aware of any issues caused by PSD, other than the increased risk of clotting and its pregnancy issues. Your INR nurse has probably assumed that you have a heart related issue because you are taking warfarin. Some people incorrectly believe we have thicker blood. Apart from the Protein S levels it is like the difference between a cup of tea with one sugar and a cup of tea with two sugars... pretty much the same as normal. There is believed to be some kind of role for Protein S in immunological issues, and blood vessel growth (which may actually swing as a benefit against some cancers) but otherwise there are no known health conditions associated. We all have other health conditions besides our PSD, and although they aren’t linked, it is sometimes necessary that the treatment for other conditions is modified to take account of the clotting considerations of PSD. For example with kidney stones we may not be suitable candidates for sonic-breakup and have to pass them instead. Any consultant that works on heart conditions will already be very familiar with clotting conditions like ours.
  12. Graveyard shifts

    Protein S Deficiency increases the risk of venous clotting (blood moves slower in the veins). Clopidogrel is an anti-platelet medication and better suited for prevention of arterial clotting (blood moves faster in the arteries). Aspirin falls into the same category. Maybe your doctor has other reasons for recommending Clopidogrel - warfarin is usually used for people with PSD and a history of clotting. When I was in my early twenties I worked in a call centre on a graveyard shift (BT ASO Grade 2) and found it affected my appetite. Warfarin is affected by diet so this is probably something to watch out for if you start taking it. It’s also difficult to stretch your legs when you are hooked up by your headset so make the most of your breaks.
  13. Don’t bother with aspirin. Aspirin will not prevent you from getting thrombosis. Please speak to your doctor before making any changes to your routine medication.
  14. Blood clotting is a process with many stages and interactions. If you make a comparison to baking a cake you probably know that leaving out a key ingredient, such as the flour, will affect the end result. Similarly adding more of other ingredients, such as the sugar, may tweak the results slightly. Changing other ingredients, such as the raising agent, could give wild and unpredictable results. When it comes to Protein S Deficiency, making changes to your diet may be helpful but it isn’t going to fix the underlying issue. You will still have that risk factor to take into account. However don’t let that stop you from aiming for a healthier lifestyle.
  15. I am on warfarin and take a multivitamin every day. It is called Seven Seas Multibionta Vitality and the Vitamin K content is 22.5 micrograms (30% NRV / RDA)