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Zarin

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  1. Scientists Develop a Test to Measure the Potential of Blood Clot Recurrence Researchers at the Medical University of Vienna have developed a new test that may help predict the recurrence of blood clots in the veins, known as venous thromboembolism (VTE). VTE has two forms: deep-vein thrombosis (DVT) and pulmonary thromboembolism (PE). DVT occurs when a clot forms deep in veins, usually in the lower extremities (legs, thighs or hip area), and is often associated with pain and swelling. When one of these clots partially or completely breaks free, it can travel through the bloodstream and lodge in the lungs, causing an embolism. PE is a serious complication that can result in permanent damage to the lungs and, in some cases, death. Dr. Gregor Hron and his colleagues have determined that in the future by measuring the blood protein thrombin, healthcare providers can predict the likelihood of a patient experiencing a second VTE. Patients could then be further classified as either at high or low risk for a recurrence. The ability to better assess the probability of future blood clots would allow doctors to make more informed treatment decisions, especially whether or not to prescribe anticoagulant heparin therapy. The study, "Identification of Patients at Low Risk for Recurrent Venous Thromboembolism by Measuring Thrombin Generation," was published in the July 26, 2006 issue of the Journal of the American Medical Association. A total of 914 patients who had previously experienced a VTE were monitored for an average of 47 months after completing their initial treatment. During that time, 100 patients in the study experienced a second clot. Investigators found that two-thirds of the patients showed lower levels of thrombin production, corresponding with a 60% reduced risk of recurrent clots. The other one-third produced significantly greater amounts of thrombin. "Using a simple, commercially available laboratory method developed to measure thrombin generation, we were able to identify patients in whom the long-term risk of recurrent venous thromboembolism is almost negligible," reported study authors. Anticipating recurrent VTE takes on even more significance when taking into account the side effects of anticoagulant therapy. By helping doctors make more informed treatment decisions, these tests could potentially spare low thrombin-producing patients from having to endure unnecessary treatment side effects. "Considering the incidence rates of severe or fatal hemorrhage related to anticoagulant therapy and the case fatality rate of recurrent venous thromboembolism, patients with low peak thrombin generation would almost certainly not benefit from indefinite anticoagulant therapy. Consequently, extensive thrombophilia screening appears to be unnecessary in this large, low-risk patient group," added study authors. Source: HealthDay News, July 25, 2006
  2. ClotCare has some new postings available. Excerpts from and links to the new postings are below. What is the d-Dimer test? Henry I. Bussey, Pharm.D., FCCP, FAHA This question has both a simple and a complex answer. The simple answer is that the d-Dimer test is a blood test used to rule out active blood clot formation. If you have a negative (normal) d-Dimer result, that nearly rules out the possibility that you have a blood clot actively forming. If you have an elevated d-Dimer test reult, that does not mean that you have a blood clot; rather an elevated d-Dimer result means that additional testing may be needed to see if a blood clot exists. If you would like to know more detail about the d-Dimer test, read on... When the clotting system is activated to form a clot, part of the process produces a substance called thrombin. Thrombin has several functions, one of which is to covert a clotting protein, fibrinogen, to fibrin. Fibrin molecules then link together to form a net of protein strands that form the basis of the clot. One of the other functions of thrombin is to activate the body's own clot dissolving ("fibrinolytic") system. In this manner, thrombin both activates the last step in the clot formation process, and it activates the system that helps dissolve clots. These two opposing functions ideally help the body form a clot where it is needed while, at the same time, limiting the size of the clot so that excessive clotting does not occur. When the body's clot dissolving system starts to dissolve the clot, that produces fibrin fragments known as d-Dimers. An increase in d-Dimer levels may mean that the clot dissolving system has been activated; but d-Dimers also can be increased by other factors such as infection, inflammation, pregnancy, etc. The complete posting is available on ClotCare at http://www.clotcare.com/clotcare/faq_ddimertest.aspx. -------------------------------------------------------------------------------- ClotCare Editorial Board Member Henry I. Bussey, Pharm.D. Honored with Pinnacle Award Marie B. Walker ClotCare's senior editor, Henry I. Bussey, Pharm.D., was recently honored with the 2006 Pinnacle Award given by the American Pharmacists Association (APhA) Foundation. Dr. Bussey was selected for this award, in part, for his work on ClotCare. In the interest of full disclosure, I should point out that Dr. Bussey is my father (see http://www.clotcare.com/clotcare/aboutclotcare.aspx). Thus, rather than brag about my dad, which I certainly could do, I have provided a press release that describes the award, including information about Dr. Bussey and the recipients from the two other award categories. The press release about the Pinnacle Award is available on ClotCare at http://www.clotcare.com/clotcare/pinnacleaward.aspx. -------------------------------------------------------------------------------- FDA Approves New Medical Use for Plavix Drug Benefits Patients with Common Form of Heart Attack The Food and Drug Administration (FDA) today approved the use of Plavix (clopidogrel bisulfate) for patients who have had a type of heart attack called acute ST-segment elevation myocardial infarction (STEMI), who are not going to have coronary artery repair (angioplasty). A STEMI is a severe heart attack caused by the sudden, total blockage of an artery. In STEMI patients, Plavix prevents subsequent blockage in the already-damaged heart vessel, which could lead to more heart attacks, stroke - and possibly death. The complete FDA press release is available on ClotCare at http://www.clotcare.com/clotcare/plavixforstemi.aspx. -------------------------------------------------------------------------------- Tom Bolser's DVT Story Tom Bolser -------------------------------------------------------------------------------- Editor's Note: (from Marie B. Walker) Julie and Tom Bolser were touched by ClotCare's efforts to promote awareness of deep vein thrombosis (DVT) and pulmonary embolism (PE) and wanted to share their story with others via ClotCare in hopes that it might help someone else faced with a possible DVT or PE. -------------------------------------------------------------------------------- I was an active 52 year old male at the time of the first incident. My wife (Julie) was a school teacher, so during her spring break we liked to travel. We had traveled to Martinique from Seattle. It was a long flight going down because we were using our air miles. While playing in the ocean the day before our return, I felt something strike the back of my leg. When I got out I could hardly walk on it. Julie helped me to a lounge chair and got ice and we elevated and iced the leg. Tom's complete story is available on ClotCare at http://www.clotcare.com/clotcare/dvtstorytombolser.aspx. -------------------------------------------------------------------------------- As always I hope the new postings are interesting and useful to you. Please let me know if you have any questions or comments. Sincerely, Marie B. Walker Director of Information Technology and Lay Editor ClotCare Online Resource Member Organization of the Coalition to Prevent Deep Vein Thrombosis http://www.clotcare.com ClotCare Online Resource is supported by unrestricted education grants and a sponsorship provided by AstraZeneca, sanofi-aventis U.S. LLC, Upsher-Smith, Pharmion, and Boehringer Ingelheim. ClotCare Online Resource is for informational purposes only. ClotCare Online Resource does NOT provide medical advice. In using ClotCare Online Resource, including this email communication, you agree to our Terms, Conditions, and Privacy Statement, which can be viewed at http://www.clotcare.com/clotcare/termsconditionsprivacy.aspx.
  3. Across Europe and Austral-Asia there is now an alternative to Wafarin Sodium(Coumadin). It is a chinese herb called Ginko Biloba. It has been approved by hospitals as a circulation enhancer and is available in a graded dosage. Here, in Malaysia, we get the approved one from Blackmoore's and it is called Ginko Forte 2000. The contents = 40mg of Ginko Biloba. It is in tablet form and is taken 3 times a day. I am highly prone to DVTs and also extremely allergic to Wafarin Sodium. I take the approved dosage of Ginko Biloba. In addition I also take 400 iu of Vit E to neutralise any dietary intake of vit K.
  4. Listen to James. I agree, asprin is not going to be enough to prevent a blood clot. I too have multiple clotting disorders. While I do not take Wafarin Sodium(Coumadin) any longer, I do take alternative herbals to keep my blood anti-coagulated. I have a blog on the subject http://Life-is-a-Leaky-Bucket.blogspot.com/
  5. Thanks James. When ever I see something like the article you posted, I cut and paste and e-mail my doctor a copy for his reference. I hope everyone else does the same.
  6. Correction. We are metric, the dosage is 0.2 ml not as I had said, 0.2 mg. Across Europe and Austral-Asia there are a few branded names being recommended for alternatives to wafarin sodium. The basic ingredient is Ginko Biloba in a specific dosage, not the usual variety available through health stores.
  7. BlueEyes, What ever is a 'prophylactic' dose? whenever I have needed to take LMWH it has always been calculated according to my weight. As you may know, I do not take allopathic medications, but maintain myself on alternatives. I am very prone to DVTs and cannot count the number I have had! I would still take shots of LMWH if I were to engage in any high risk activity, like flying. I am guessing that this prophylactic dose is 0.2mg injections, commonly used for keeping a patient anti-coagulated during dialysis, and often given these days to patients undergoing surgery. If you have inherent PSD you may want to consider the option of a properly calculated dose...just incase... As for bloodwork, I need to think about that before I respond. If you are on a calculated dose of LMWH no blood work is necessary as far as I know.
  8. The dosage for LMWHeparin injections is calculated according to your body weight. You should not be afraid that it will not work. Provided you take the correct dosage, you should not encounter any problems.
  9. Thank you James for the two articles. They are very useful and informative. I have e-mailed a copy to my doctor so that he too has a greater awareness.
  10. Hi and welcome to our little 'club'. I too have PSD and PCD and have been dealing with it for over 20 years. With good management, life goes on as usual
  11. LMWHeparin is used to dissolve blood clots. Wafarin Sodium acts through the liver, blocking the vit. K(clotting factor) factor. It will not dissolve blood clots, but will act as a preventative measure from new clots forming.
  12. Good management is the key. I have been dealing with PSD and PCD since the mid- 80s. What ever route you choose to take, it is important to manage the condition. What medication is your dad on?
  13. I cannot recall how many DVTs I have had. Initially, when I first needed to get my teeth cleaned, I was weaned off wafarin. Only to clot on the fourth day. Subsequently, I was put on heparin, even for basic dental hygine. I started having DVTs in the late '80s when little was known about inherent blood clotting disorders. My nightmares are chronicled in my book. I also had a stroke, but recovered completely from it, without damage. For my stroke, I was treated with Ginko Biloba. Ginko Biloba is now being used across Europe and Austral-Asia as an alternative circulation enhancer. I should add, taking Ginko Biloba has also resulted in improving my brain functions. I can now do calculations faster than a calculator,lol!
  14. I am suprised you were not advised adequately and had to go through such trauma for your dental work. If you are on Coumadin(wafarin sodium) 4 days prior to any dental work, you need to begin LMWHeparin injections and remain on them while you are weaned off Coumadin. Then get your dental work done, and only then do you start building back your INR by re-introducing Coumadin. All through this you will need to remain on LMWHeparin. The process takes about 8 to 10 days.
  15. Very little is known about blood clotting disorders anywhere. From my own personal experience USA is the least educated on the subject. My advise is do your own research and share it with the primary care giver. This is what I do. I too am a north Indian, living in Malaysia. When I was first diagnosed, my doctor was honest enough to say he knew very little about PSD and PCD. Today, I do believe he is the most educated doctor on this subject.
  16. Hi I am posting this as I do not know how many of you are on this list.Zarin The DVT team The DVT Team of doctors, nurses, and nutrition and fitness experts offers more news and information about DVT blood clots. Read the second issue of Know Your Risk Update?the newsletter of the Know Your Risk Program. The DVT Team discusses 4 tests doctors use to diagnose DVT. If you are at risk for developing more DVT blood clots, your doctor may give you a test to help make a diagnosis. H20 for health Find out how much water you should drink to stay hydrated in the DVT Team Corner of Know Your Risk Update. Reduce your risk factors Help reduce your risk of developing more DVT blood clots with 4 simple calf stretches that combat immobility, explained in Diet & Exercise Notes. Learn how support stockings offer everyday help for DVT blood clots in Life After DVT. Knowledge gives you the power to help protect against DVT. View Newsletter >
  17. I was 24 when I had to have a hysterectomy, so I do not relate to pregnancies. However, after hearing you, I would have to say, stay on your LWMHeparin. LMWH shots are calculated according to body weight, so I would bring that up. Rule of thumb, 0.1 mg per 10 kg of weight.
  18. Hyacinth, During the time I was on Wafarin Sodium(Coumadin), whenever I needed to do a blood test, ( this is for determining the levels of the various clotting factors that we know of) I was weaned off Wafarin Sodium and put on LMWHeparin and the blood test was done while I was on the injections. I have an understanding with my doctor. As I do research on clotting factors, I e-mail a copy to my primary care giver. This way he is equipped with as much information as I have. I also gave him a copy of my book to read What you need at this stage, I am guessing, is a good haemotologist. Once you have your blood work organised, it is fine to be under the care of your GP.
  19. You need to have a complete blood profile done. Please note, that for this test they need about 1/2 pint of blood. You should carry a fruit or something sweet for afterwards. I am a bit confused why they could not do the test while you were on LMWHeparin, as it does not interfere with the test.
  20. It is truely unfortunate that so little is known about blood clots and the consequences of having one. We have heart specialists. A coronory thrombosis is a blood clot in the heart, and yet we call it a heart attack and get some one to specialise in treating it in isolation to the root cause. If we have a cerebral embolism it is called a stroke and we are marched off to a neurologist. I was just talking to someone yesterday, her mother had a pulmonory embolism. No one is looking for the root of her problem. I directed her to this website as I dont know of anywhere else she could go to equip herself with more information. Cancer and AIDs are not the biggest killer, blood clots are.( there maybe a slogan in here somewhere). The truth of the matter is, for the several clotting disorders known the ratio of unknown ones is mind boggling. Dorctors are unaware and therefore cover-up by wrapping everthing up in jargon. My latin is not very good, but coming as I do from a family of doctors, and being a qualified psychologist myself, they dont fool me! I have asked my husband to come up with a few slogans. I will also contact other family members in the advertising business to help. For now, 'dont be a clot" seems to be the best.
  21. Hi Cilla and welcome! If can make the time to read the archives on pregnancies you will find most of your answers. In brief, if you have PSD, you do need to be on LMWHeparin injections during the term of your pregnancy. Blood protein levels do fluctuate, so blood tests can vary in results. It often has to do with your food intake. Both Protein c and s are produced by your liver. Your diet will affect the levels and show up in your blood work. Good luck.
  22. Are you on a permanent dose of wafarin sodium? Generally, if you are driving, it is best to take a break every hour. You can also flex your leg muscles while driving, just to keep them active. I totally understand your paranoia, I was like that. It does get better. It is important you do not stress yourself.
  23. Good luck Allie! Hope you have started your LMWHeparin injections. Protein S levels do drop with pregnancy, so it is important to take the injections. Please remember that the injections are calculated according to your body weight; this will ensure you have the correct dosage throught out your pregnancy.
  24. I had a hysterectomy when I was 24years old. I am 53 now, and have never had any regrets. The best thing that happened to me! I had my ovaries left, but had to have the cervix removed as I was pre-cancerous. If you leave your cervix, let me describe what to expect. What they will do is channel the fallopian tubes to the cervix. This will result in occasional spotting. You will also run the risk of cervical cancer in later years. If the cervix is removed, they will seal the vaginal vault with dissolving stitches, which you then have to count as they pop out, to ensure they have all come out. Sexually, having the cervix removed has no side effects. Good luck.
  25. If you are on a permanent dose of wafarin sodium(Coumadin) and your INR is being maintained at a suitable level, you have nothing to worry about. Yes, this is a great site, thanks to James! Good luck.
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