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Hereditary Thrombophilia Testing Among Hospitalized Patients: Is It Warranted?


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Hereditary Thrombophilia Testing Among Hospitalized Patients: Is It Warranted?

Omar K. Abughanimeh , Rosalyn I. Marar, Mohammad Tahboub, Anahat Kaur, Ayman Qasrawi, Mouhanna Abu Ghanimeh, Timothy Pluard
Published: May 09, 2022 (see history) DOI: 10.7759/cureus.24855

Cite this article as: Abughanimeh O K, Marar R I, Tahboub M, et al. (May 09, 2022) Hereditary Thrombophilia Testing Among Hospitalized Patients: Is It Warranted?. Cureus 14(5): e24855. doi:10.7759/cureus.24855

Hereditary thrombophilias (HTs) are a group of inherited disorders that predispose the carrier to venous thromboembolism (VTE). It is estimated that 7% of the population has some form of HT. Although testing for HT has become routine for many hospitalized patients, knowing when to order the tests and how to interpret the results remains challenging. In the United States, there are no clear guidelines regarding testing for HT. We conducted a study to evaluate the utilization of HT testing among hospitalized patients to examine its impact on immediate management decisions and overall cost burden. In addition, we discuss the common reasons for healthcare providers to order these tests and review the data behind these reasons in the literature.

Our study demonstrated that HT testing during hospitalization had a limited role in changing management and was associated with a significant cost. The decision to order HT tests should be considered following an individualized clinical risk assessment.

https://www.cureus.com/articles/92682-hereditary-thrombophilia-testing-among-hospitalized-patients-is-it-warranted

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