Can PSD skip a generation?

[m2missy]

I found out I had PSD when I was about 12 weeks pregnant, I have read on this site that in order for it to be hereditary that you have to get it from your mother or father, that it doesnt skip generations. I had both my parents tested and they were negative, so I got tested about 8 weeks post partem, and tested deficient. So my main question is did I test to early and if so How long should I wait?

Any info would be great

Missy

[James]

Missy, you need your doctor to interpret your results based on your medical history. It is their responsibility! But if you want to form your own conclusions can I suggest you read the following page... http://www.emedicine.com/med/topic1924.htm which says "Protein S deficiency may be hereditary or acquired, the latter usually is due to hepatic diseases or a vitamin K deficiency. Protein S deficiency usually manifests clinically as venous thromboembolism (VTE). The association of protein S deficiency with arterial thrombosis appears coincidental or weak at best. Arterial thrombosis is not evident with other hereditary anticoagulant abnormalities (eg, protein C or antithrombin III deficiency, factor V Leiden gene mutation). Protein S deficiency manifests as an autosomal dominant trait; manifestations of thrombosis are observed in both heterozygous and homozygous genetic deficiencies of protein S."

Then read this page on how Autosomal Dominant Inheritance works... http://www.jewishgenetics.org/auto_dom.htm

Then read what Dr Moll says at http://www.fvleiden.org/ask/50.html and also http://www.fvleiden.org/ask/49.html where he says "Neither protein S deficiency, nor factor V Leiden "skip a generation"."

I recommend reading all of the pages I've referenced in full.

[m2missy]

James- Thanks for taking the time to respond with all the helpful and informative

links. I have not seen a doctor who seems to know a whole lot about PSD, I plan on seeing a heamatologist (sp?) but I was hoping that mine was pregnancy acquired and that possibly I tested to early. I have no history of DVT or PE.

Thanks again,

Missy

[Guest Grace]

Hi Missy,

After I lost my baby this summer, my perinatologist wanted to wait 3 months before retesting my blood to see if I still had PSD. Unfortunately, that never got to happen because I ended up in the hospital with an infected ovarian vein thrombosis and was placed on Warfarin. I'll be on it for a total of 6 months, and will be stopping it the first week of Feb. They'll retest me 4 weeks later.

It's a big difference between 3 months and 4 weeks, I know. I think the difference must be that pregnancy hormones take longer to get out of your system, and for everything to get back to normal, than it does for the Protein S levels in your body to build back up after stopping Warfarin/Coumadin.

So, what I'm trying to say is, give it more time. Perhaps wait another month or two? Have you asked your hematologist about it? Good luck.

Grace