Hazards and Warnings
Warnings about products, services, information or anything else considered to increase risks and hazards for people with PSD will be published on this page.
Octaplas presents a transfusion risk for patients with Protein S Deficiency
Octaplas is the only FDA-licensed pooled, solvent/detergent (S/D) treated plasma for transfusion. The FDA has recently approved revised product handling for Octaplas, which increases the time span between product thawing and patient administration.
Octaplas is indicated for the replacement of multiple coagulation factors in patients with acquired deficiencies due to liver disease, undergoing cardiac surgery or liver transplant; and for plasma exchange in patients with thrombotic thrombocytopenic purpura (TTP). More than 13.5 million bags of Octaplas have been transfused to more than 4.5 million patients worldwide.
However excessive bleeding due to hyperfibrinolysis can occur due to low levels of alpha2-antiplasmin, and thrombosis can occur due to low levels of Protein S. Therefore Octaplas is contraindicated in patients with Protein S Deficiency.
- Further information is available from www.octaplasus.com
Recommendation to limit intake of Cranberry Juice
The BMJ (British Medical Journal) has published an article which suggests that there is a possible interaction between warfarin and cranberry juice. The author recommends that until further research is conducted anyone taking warfarin (or Coumadin) should limit their intake of cranberry juice.
Giving Blood Can Put You At Risk
The UK National Blood Service have advised that people with Protein S Deficiency and a history of clotting or taking anti-coagulants should not donate blood. If you call the UK National Blood Service on 0300 123 23 23 it is best to ask for the assistance of a specialist advisor.
Update 23/Aug/2001: In 2001 it was said that even if you are not on medication the process of transfusion itself is a risk factor to the donor - your blood pressure will drop and this could cause thrombosis
Update 16/Mar/2016: In 2016 the advice was relaxed to allow donations from those with Protein S Deficiency and no clotting history and not taking anti-coagulants.
Disclaimer: For your own health and safety you should always seek the advice of a qualified medical practitioner and not act on information published on this web site. No responsibility can be accepted for the content or absence of content published on this site for any reason.
Last updated: Wednesday, 3rd January 2018
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